The ancient art of origami is probably as old as paper, yet only recently has it been recognized as a framework for engineering new devices and materials. For the past several years, our group has been developing an origami approach to mechanical metamaterials, materials that exhibit designed mechanical response at long length scales by virtue of their structure at short length scales, as well as an approach to fabricating self-folding materials. In this talk, I will discuss our recent progress in designing and fabricating self-folding origami structures and mechanical metamaterials.