Polyethylene glycol (PEG) is a nonimmunogenic hydrophilic polymer that can be use as a carrier media to decrease opsonization of drugs from the human body and increase blood circulation time. To exploit the properties of PEG, drugs may be PEGylated by reaction of a drug molecule with carefully selected reactive end-groups on PEG. However, PEGylation is typically limited to one drug molecule per PEG. We are working on a novel approach that will enable attachment of many functional groups along the backbone of PEG by copolymerization of ethylene oxide with propargyl glycidyl ether. We synthesized propargyl glycidyl ether in high yield and purity, and carried out polymerization by both activated-monomer, and oxyanionic polymerization. The activated-monomer resulted in no polymer formation. However, oxyanionic polymerization resulted in the formation of polymer with a number-average molecular weight of 9 kDa, and a polydispersity of 2.3.